Interactions médicamenteuses
Amitriptyline + Epinephrine
Gravité: Majeure
Amitriptyline and Epinephrine: major interaction.
Dernière mise à jour
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Résumé
Tricyclics block norepinephrine reuptake and sensitise adrenergic receptors, so systemic epinephrine can cause exaggerated hypertension, tachycardia and arrhythmias. The effect is most important with parenteral or large doses, whereas small amounts in dental local anaesthetics carry less risk.
Ce que signifie cette interaction, en termes simples
Amitriptyline and Epinephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Epinephrine belongs to Endocrine.
Pourquoi elle survient
Tricyclic blockade of catecholamine reuptake potentiates pressor and arrhythmogenic responses to epinephrine.
Conduite à tenir
Use the lowest effective epinephrine dose with continuous blood pressure and ECG monitoring when systemic use is needed. Limit epinephrine in local anaesthetics and avoid intravascular injection.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Amitriptyline
- Amitriptyline + Isocarboxazid Contre-indiquée
- Amitriptyline + Methylene blue Contre-indiquée
- Amitriptyline + Phenelzine Contre-indiquée
- Amitriptyline + Pimozide Contre-indiquée
- Amitriptyline + Procarbazine Contre-indiquée
- Amitriptyline + Safinamide Contre-indiquée
Autres interactions de Epinephrine
- Epinephrine + Isocarboxazid Contre-indiquée
- Epinephrine + Phenelzine Contre-indiquée
- Epinephrine + Tranylcypromine Contre-indiquée
- Acebutolol + Epinephrine Majeure
- Amoxapine + Epinephrine Majeure
- Atenolol-chlorthalidone + Epinephrine Majeure
Questions fréquentes
Can I take Amitriptyline with Epinephrine?
MediHelp rates the interaction as major. Amitriptyline and Epinephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclics block norepinephrine reuptake and sensitise adrenergic receptors, so systemic epinephrine can cause exaggerated hypertension, tachycardia and arrhythmias. The effect is most important with parenteral or large doses, whereas small amounts in dental local anaesthetics carry less risk.
How serious is the interaction between Amitriptyline and Epinephrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective epinephrine dose with continuous blood pressure and ECG monitoring when systemic use is needed. Limit epinephrine in local anaesthetics and avoid intravascular injection.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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