Interactions médicamenteuses
Epinephrine + Isocarboxazid
Gravité: Contre-indiquée
Epinephrine and Isocarboxazid: contraindicated interaction.
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Résumé
Epinephrine is partly cleared by MAO and COMT, and isocarboxazid inhibits monoamine oxidase, which prolongs and intensifies its pressor action. Hypertensive crisis and arrhythmia may follow, especially with systemic dosing.
Ce que signifie cette interaction, en termes simples
Epinephrine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Epinephrine belongs to Endocrine; Isocarboxazid belongs to Central Nervous System.
Pourquoi elle survient
MAO inhibition potentiating sympathomimetic effects
Conduite à tenir
Avoid systemic epinephrine; if essential for anaphylaxis, use titrated doses with blood pressure and ECG monitoring.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Isocarboxazid
- 5-HTP + Isocarboxazid Contre-indiquée
- Amitriptyline + Isocarboxazid Contre-indiquée
- Amobarbital + Isocarboxazid Contre-indiquée
- Amoxapine + Isocarboxazid Contre-indiquée
- Apraclonidine + Isocarboxazid Contre-indiquée
- Atomoxetine + Isocarboxazid Contre-indiquée
Autres interactions de Epinephrine
- Epinephrine + Phenelzine Contre-indiquée
- Epinephrine + Tranylcypromine Contre-indiquée
- Acebutolol + Epinephrine Majeure
- Amitriptyline + Epinephrine Majeure
- Amoxapine + Epinephrine Majeure
- Atenolol-chlorthalidone + Epinephrine Majeure
Questions fréquentes
Can I take Epinephrine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Epinephrine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Epinephrine is partly cleared by MAO and COMT, and isocarboxazid inhibits monoamine oxidase, which prolongs and intensifies its pressor action. Hypertensive crisis and arrhythmia may follow, especially with systemic dosing.
How serious is the interaction between Epinephrine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic epinephrine; if essential for anaphylaxis, use titrated doses with blood pressure and ECG monitoring.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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