Interactions médicamenteuses
Atidarsagene autotemcel + Tenofovir disoproxil
Gravité: Majeure
Atidarsagene autotemcel and Tenofovir disoproxil: major interaction.
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Résumé
Antiretrovirals can interfere with the manufacture of gene-modified autologous cell products by inhibiting lentiviral transduction. Tenofovir taken before and during cell collection may reduce the quality of the product.
Ce que signifie cette interaction, en termes simples
Atidarsagene autotemcel and Tenofovir disoproxil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Antiretroviral inhibition of lentiviral vector transduction of harvested cells during manufacturing.
Conduite à tenir
Stop antiretrovirals for at least one month, or longer for long-acting agents, before cell mobilization and until apheresis is complete. Coordinate with the HIV specialist on management of the interruption.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Atidarsagene autotemcel
Questions fréquentes
Can I take Atidarsagene autotemcel with Tenofovir disoproxil?
MediHelp rates the interaction as major. Atidarsagene autotemcel and Tenofovir disoproxil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antiretrovirals can interfere with the manufacture of gene-modified autologous cell products by inhibiting lentiviral transduction. Tenofovir taken before and during cell collection may reduce the quality of the product.
How serious is the interaction between Atidarsagene autotemcel and Tenofovir disoproxil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop antiretrovirals for at least one month, or longer for long-acting agents, before cell mobilization and until apheresis is complete. Coordinate with the HIV specialist on management of the interruption.
What other medicines interact with Atidarsagene autotemcel?
MediHelp also lists interactions of Atidarsagene autotemcel with, for example, Didanosine, Dolutegravir, Efavirenz. The full list is on the Atidarsagene autotemcel page.
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