Interactions médicamenteuses
Atidarsagene autotemcel + Lamivudine
Gravité: Majeure
Atidarsagene autotemcel and Lamivudine: major interaction.
Dernière mise à jour
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Résumé
Antiretrovirals such as lamivudine can interfere with manufacture of the gene-modified cell product because they inhibit the lentiviral vector transduction process. Patients taking them around the time of cell collection may produce an inadequate or unusable product.
Ce que signifie cette interaction, en termes simples
Atidarsagene autotemcel and Lamivudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atidarsagene autotemcel belongs to Miscellaneous; Lamivudine belongs to Anti Virals.
Pourquoi elle survient
Nucleoside reverse transcriptase inhibitors block reverse transcription of the lentiviral vector, impairing transduction of harvested cells.
Conduite à tenir
Stop lamivudine at least one month before cell mobilization, or longer for drug elimination, and keep it off until apheresis is complete. Consult an HIV specialist for an alternative plan.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Lamivudine
Autres interactions de Atidarsagene autotemcel
Questions fréquentes
Can I take Atidarsagene autotemcel with Lamivudine?
MediHelp rates the interaction as major. Atidarsagene autotemcel and Lamivudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antiretrovirals such as lamivudine can interfere with manufacture of the gene-modified cell product because they inhibit the lentiviral vector transduction process. Patients taking them around the time of cell collection may produce an inadequate or unusable product.
How serious is the interaction between Atidarsagene autotemcel and Lamivudine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop lamivudine at least one month before cell mobilization, or longer for drug elimination, and keep it off until apheresis is complete. Consult an HIV specialist for an alternative plan.
What other medicines interact with Lamivudine?
MediHelp also lists interactions of Lamivudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Betibeglogene autotemcel, Elivaldogene autotemcel. The full list is on the Lamivudine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
