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Interactions médicamenteuses

Avanafil + Tipranavir

Gravité: Contre-indiquée

Avanafil and Tipranavir: contraindicated interaction.

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Résumé

Tipranavir, which is given with ritonavir, strongly inhibits CYP3A4 and can markedly raise avanafil exposure. This may cause profound hypotension, syncope, visual disturbances and prolonged erection or priapism.

Ce que signifie cette interaction, en termes simples

Avanafil and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Avanafil belongs to Genitourinary; Tipranavir belongs to Anti Virals.

Niveau de preuve: High

Pourquoi elle survient

Ritonavir-boosted tipranavir inhibits CYP3A4-mediated first-pass and hepatic metabolism of avanafil, reducing its clearance.

Conduite à tenir

Do not combine avanafil with ritonavir-boosted tipranavir. Choose a non-CYP3A4-dependent option for erectile dysfunction, or use a PDE5 inhibitor at a labeled reduced dose with specialist advice.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Avanafil with Tipranavir?

MediHelp rates the interaction as contraindicated. Avanafil and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tipranavir, which is given with ritonavir, strongly inhibits CYP3A4 and can markedly raise avanafil exposure. This may cause profound hypotension, syncope, visual disturbances and prolonged erection or priapism.

How serious is the interaction between Avanafil and Tipranavir?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine avanafil with ritonavir-boosted tipranavir. Choose a non-CYP3A4-dependent option for erectile dysfunction, or use a PDE5 inhibitor at a labeled reduced dose with specialist advice.

What other medicines interact with Avanafil?

MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.

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