Drug interactions
Avanafil + Tipranavir
Severity: Contraindicated
Avanafil and Tipranavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, which is given with ritonavir, strongly inhibits CYP3A4 and can markedly raise avanafil exposure. This may cause profound hypotension, syncope, visual disturbances and prolonged erection or priapism.
What this interaction means in plain words
Avanafil and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Avanafil belongs to Genitourinary; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted tipranavir inhibits CYP3A4-mediated first-pass and hepatic metabolism of avanafil, reducing its clearance.
What to do
Do not combine avanafil with ritonavir-boosted tipranavir. Choose a non-CYP3A4-dependent option for erectile dysfunction, or use a PDE5 inhibitor at a labeled reduced dose with specialist advice.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
- Dronedarone + Tipranavir Contraindicated
Frequently asked questions
Can I take Avanafil with Tipranavir?
MediHelp rates the interaction as contraindicated. Avanafil and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tipranavir, which is given with ritonavir, strongly inhibits CYP3A4 and can markedly raise avanafil exposure. This may cause profound hypotension, syncope, visual disturbances and prolonged erection or priapism.
How serious is the interaction between Avanafil and Tipranavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine avanafil with ritonavir-boosted tipranavir. Choose a non-CYP3A4-dependent option for erectile dysfunction, or use a PDE5 inhibitor at a labeled reduced dose with specialist advice.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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