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Interactions médicamenteuses

Avapritinib + Cetirizine

Gravité: Modérée

Avapritinib and Cetirizine: moderate interaction.

Dernière mise à jour

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Résumé

Avapritinib can cause cognitive effects such as memory impairment, confusion and drowsiness, and cetirizine may add to sedation. The combination may worsen mental clouding.

Ce que signifie cette interaction, en termes simples

Avapritinib and Cetirizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Avapritinib belongs to Oncology; Cetirizine belongs to Respiratory.

Niveau de preuve: Low

Pourquoi elle survient

Additive CNS depressant effects; avapritinib has its own neurocognitive toxicity.

Conduite à tenir

Monitor cognition and alertness, and use a nonsedating alternative or lower cetirizine dose if cognitive symptoms appear. Follow avapritinib dose-modification guidance for cognitive adverse effects.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Avapritinib with Cetirizine?

MediHelp rates the interaction as moderate. Avapritinib and Cetirizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects such as memory impairment, confusion and drowsiness, and cetirizine may add to sedation. The combination may worsen mental clouding.

How serious is the interaction between Avapritinib and Cetirizine?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cognition and alertness, and use a nonsedating alternative or lower cetirizine dose if cognitive symptoms appear. Follow avapritinib dose-modification guidance for cognitive adverse effects.

What other medicines interact with Cetirizine?

MediHelp also lists interactions of Cetirizine with, for example, Acrivastine, Amisulpride, Asenapine. The full list is on the Cetirizine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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