Drug interactions
Avapritinib + Cetirizine
Severity: Moderate
Avapritinib and Cetirizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects such as memory impairment, confusion and drowsiness, and cetirizine may add to sedation. The combination may worsen mental clouding.
What this interaction means in plain words
Avapritinib and Cetirizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Cetirizine belongs to Respiratory.
Why it happens
Additive CNS depressant effects; avapritinib has its own neurocognitive toxicity.
What to do
Monitor cognition and alertness, and use a nonsedating alternative or lower cetirizine dose if cognitive symptoms appear. Follow avapritinib dose-modification guidance for cognitive adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cetirizine
- Acrivastine + Cetirizine Moderate
- Amisulpride + Cetirizine Moderate
- Asenapine + Cetirizine Moderate
- Benzhydrocodone / acetaminophen + Cetirizine Moderate
- Brexpiprazole + Cetirizine Moderate
- Brivaracetam + Cetirizine Moderate
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Cetirizine?
MediHelp rates the interaction as moderate. Avapritinib and Cetirizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects such as memory impairment, confusion and drowsiness, and cetirizine may add to sedation. The combination may worsen mental clouding.
How serious is the interaction between Avapritinib and Cetirizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cognition and alertness, and use a nonsedating alternative or lower cetirizine dose if cognitive symptoms appear. Follow avapritinib dose-modification guidance for cognitive adverse effects.
What other medicines interact with Cetirizine?
MediHelp also lists interactions of Cetirizine with, for example, Acrivastine, Amisulpride, Asenapine. The full list is on the Cetirizine page.
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