Interactions médicamenteuses
Axicabtagene ciloleucel + Cladribine
Gravité: Majeure
Axicabtagene ciloleucel and Cladribine: major interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Cladribine is toxic to lymphocytes and may impair collection or expansion of T cells, and may reduce CAR-T cell function and persistence. The combination also adds to immunosuppression and infection risk.
Ce que signifie cette interaction, en termes simples
Axicabtagene ciloleucel and Cladribine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axicabtagene ciloleucel belongs to Oncology; Cladribine belongs to Oncology.
Pourquoi elle survient
Lymphotoxic effect of cladribine reduces T-cell numbers and function, affecting CAR-T manufacturing and expansion, and adds to immunosuppression.
Conduite à tenir
Avoid cladribine in the period before leukapheresis and CAR-T infusion; follow the product labeling for the washout interval. Monitor closely for infections if exposure has occurred.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Axicabtagene ciloleucel et Cladribine, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Autres interactions de Cladribine
- Adenovirus types 4 and 7 live + Cladribine Contre-indiquée
- Cladribine + Siponimod Contre-indiquée
- Cladribine + Tofacitinib Contre-indiquée
- Belatacept + Cladribine Majeure
- Brexucabtagene autoleucel + Cladribine Majeure
- Cholera vaccine + Cladribine Majeure
Autres interactions de Axicabtagene ciloleucel
Questions fréquentes
Can I take Axicabtagene ciloleucel with Cladribine?
MediHelp rates the interaction as major. Axicabtagene ciloleucel and Cladribine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cladribine is toxic to lymphocytes and may impair collection or expansion of T cells, and may reduce CAR-T cell function and persistence. The combination also adds to immunosuppression and infection risk.
How serious is the interaction between Axicabtagene ciloleucel and Cladribine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cladribine in the period before leukapheresis and CAR-T infusion; follow the product labeling for the washout interval. Monitor closely for infections if exposure has occurred.
What other medicines interact with Cladribine?
MediHelp also lists interactions of Cladribine with, for example, Adenovirus types 4 and 7 live, Siponimod, Tofacitinib. The full list is on the Cladribine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
