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Interactions médicamenteuses

Cladribine + Siponimod

Gravité: Contre-indiquée

Cladribine and Siponimod: contraindicated interaction.

Dernière mise à jour

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Résumé

Cladribine causes prolonged lymphocyte depletion, and siponimod further reduces lymphocyte counts. Combined use may produce profound, long-lasting immunosuppression with serious infection risk.

Ce que signifie cette interaction, en termes simples

Cladribine and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Cladribine belongs to Oncology; Siponimod belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive lymphocyte depletion: cladribine is cytotoxic to lymphocytes and siponimod sequesters them in lymphoid tissue.

Conduite à tenir

Do not use together; cladribine labeling advises against concomitant immunosuppressive or myelosuppressive therapy. When switching, check lymphocyte counts and allow adequate recovery before starting the second drug.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cladribine with Siponimod?

MediHelp rates the interaction as contraindicated. Cladribine and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cladribine causes prolonged lymphocyte depletion, and siponimod further reduces lymphocyte counts. Combined use may produce profound, long-lasting immunosuppression with serious infection risk.

How serious is the interaction between Cladribine and Siponimod?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; cladribine labeling advises against concomitant immunosuppressive or myelosuppressive therapy. When switching, check lymphocyte counts and allow adequate recovery before starting the second drug.

What other medicines interact with Siponimod?

MediHelp also lists interactions of Siponimod with, for example, Fingolimod, Fluconazole, Influenza virus vaccine quadrivalent intranasal. The full list is on the Siponimod page.

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