Interactions médicamenteuses
Azathioprine + Bcg vaccine live
Gravité: Contre-indiquée
Azathioprine and Bcg vaccine live: contraindicated interaction.
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Résumé
BCG is a live attenuated bacterial vaccine and can cause disseminated BCG infection in immunosuppressed patients. Azathioprine impairs the cellular immunity needed to contain it.
Ce que signifie cette interaction, en termes simples
Azathioprine and Bcg vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Azathioprine-induced suppression of T-cell function allows uncontrolled replication of live attenuated Mycobacterium bovis.
Conduite à tenir
Do not give BCG to patients on azathioprine; defer until immunosuppression has been stopped for the interval recommended by local guidance. Assess tuberculosis risk by alternative means.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contre-indiquée
- Azathioprine + Febuxostat Contre-indiquée
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contre-indiquée
- Azathioprine + Measles mumps and rubella vaccine Contre-indiquée
- Azathioprine + Measles mumps and rubella vaccine live Contre-indiquée
- Azathioprine + Measles mumps rubella and varicella vaccine live Contre-indiquée
Questions fréquentes
Can I take Azathioprine with Bcg vaccine live?
MediHelp rates the interaction as contraindicated. Azathioprine and Bcg vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. BCG is a live attenuated bacterial vaccine and can cause disseminated BCG infection in immunosuppressed patients. Azathioprine impairs the cellular immunity needed to contain it.
How serious is the interaction between Azathioprine and Bcg vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give BCG to patients on azathioprine; defer until immunosuppression has been stopped for the interval recommended by local guidance. Assess tuberculosis risk by alternative means.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Febuxostat, Influenza virus vaccine quadrivalent intranasal. The full list is on the Azathioprine page.
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