Interactions médicamenteuses
Azathioprine + Influenza virus vaccine quadrivalent intranasal
Gravité: Contre-indiquée
Azathioprine and Influenza virus vaccine quadrivalent intranasal: contraindicated interaction.
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Résumé
The intranasal influenza vaccine contains live attenuated virus, which could replicate more extensively in a patient immunosuppressed by azathioprine. This creates a risk of vaccine-strain infection, and the vaccine response may also be reduced.
Ce que signifie cette interaction, en termes simples
Azathioprine and Influenza virus vaccine quadrivalent intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Azathioprine-induced impairment of cellular immunity may allow uncontrolled replication of live attenuated virus.
Conduite à tenir
Do not use the live intranasal vaccine in patients on azathioprine. Give an inactivated injectable influenza vaccine instead.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contre-indiquée
- Azathioprine + Bcg vaccine live Contre-indiquée
- Azathioprine + Febuxostat Contre-indiquée
- Azathioprine + Measles mumps and rubella vaccine Contre-indiquée
- Azathioprine + Measles mumps and rubella vaccine live Contre-indiquée
- Azathioprine + Measles mumps rubella and varicella vaccine live Contre-indiquée
Questions fréquentes
Can I take Azathioprine with Influenza virus vaccine quadrivalent intranasal?
MediHelp rates the interaction as contraindicated. Azathioprine and Influenza virus vaccine quadrivalent intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The intranasal influenza vaccine contains live attenuated virus, which could replicate more extensively in a patient immunosuppressed by azathioprine. This creates a risk of vaccine-strain infection, and the vaccine response may also be reduced.
How serious is the interaction between Azathioprine and Influenza virus vaccine quadrivalent intranasal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use the live intranasal vaccine in patients on azathioprine. Give an inactivated injectable influenza vaccine instead.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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