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Interactions médicamenteuses

Azilsartan-chlorthalidone + Benazepril

Gravité: Majeure

Azilsartan-chlorthalidone and Benazepril: major interaction.

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Résumé

Combining an angiotensin receptor blocker with an ACE inhibitor gives dual renin-angiotensin system blockade. This increases the risk of hypotension, hyperkalemia and acute kidney injury without clear outcome benefit.

Ce que signifie cette interaction, en termes simples

Azilsartan-chlorthalidone and Benazepril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Azilsartan-chlorthalidone belongs to Cardiovascular; Benazepril belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Additive inhibition of the renin-angiotensin-aldosterone system by ARB and ACE inhibitor.

Conduite à tenir

Avoid the combination; use one RAS blocker. If unavoidable, monitor potassium, creatinine and blood pressure closely.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Azilsartan-chlorthalidone with Benazepril?

MediHelp rates the interaction as major. Azilsartan-chlorthalidone and Benazepril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an angiotensin receptor blocker with an ACE inhibitor gives dual renin-angiotensin system blockade. This increases the risk of hypotension, hyperkalemia and acute kidney injury without clear outcome benefit.

How serious is the interaction between Azilsartan-chlorthalidone and Benazepril?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use one RAS blocker. If unavoidable, monitor potassium, creatinine and blood pressure closely.

What other medicines interact with Azilsartan-chlorthalidone?

MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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