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Interactions médicamenteuses

Azithromycin + Macimorelin

Gravité: Majeure

Azithromycin and Macimorelin: major interaction.

Dernière mise à jour

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Résumé

Macimorelin causes a small QT prolongation and azithromycin can add to it. Combining them increases the risk of torsades de pointes around the diagnostic test.

Ce que signifie cette interaction, en termes simples

Azithromycin and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Azithromycin belongs to Anti Bacterial; Macimorelin belongs to Endocrine.

Niveau de preuve: Low

Pourquoi elle survient

Additive pharmacodynamic QT prolongation.

Conduite à tenir

Postpone the macimorelin test until azithromycin has been stopped and cleared; azithromycin has a long half-life, so allow a generous washout. Avoid giving both within the testing period.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Azithromycin with Macimorelin?

MediHelp rates the interaction as major. Azithromycin and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin causes a small QT prolongation and azithromycin can add to it. Combining them increases the risk of torsades de pointes around the diagnostic test.

How serious is the interaction between Azithromycin and Macimorelin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Postpone the macimorelin test until azithromycin has been stopped and cleared; azithromycin has a long half-life, so allow a generous washout. Avoid giving both within the testing period.

What other medicines interact with Azithromycin?

MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.

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