Drug interactions
Azithromycin + Macimorelin
Severity: Major
Azithromycin and Macimorelin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a small QT prolongation and azithromycin can add to it. Combining them increases the risk of torsades de pointes around the diagnostic test.
What this interaction means in plain words
Azithromycin and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azithromycin belongs to Anti Bacterial; Macimorelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Postpone the macimorelin test until azithromycin has been stopped and cleared; azithromycin has a long half-life, so allow a generous washout. Avoid giving both within the testing period.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Azithromycin with Macimorelin?
MediHelp rates the interaction as major. Azithromycin and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin causes a small QT prolongation and azithromycin can add to it. Combining them increases the risk of torsades de pointes around the diagnostic test.
How serious is the interaction between Azithromycin and Macimorelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Postpone the macimorelin test until azithromycin has been stopped and cleared; azithromycin has a long half-life, so allow a generous washout. Avoid giving both within the testing period.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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