Interactions médicamenteuses
Baclofen + Benzhydrocodone / acetaminophen
Gravité: Majeure
Baclofen and Benzhydrocodone / acetaminophen: major interaction.
Dernière mise à jour Sources: UK SmPC
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Résumé
Combining baclofen with an opioid such as benzhydrocodone adds to central nervous system and respiratory depression. Profound sedation, respiratory depression, coma and death can occur, especially at higher doses or in vulnerable patients.
Ce que signifie cette interaction, en termes simples
Baclofen and Benzhydrocodone / acetaminophen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive pharmacodynamic CNS depression from opioid receptor agonism and GABA-B agonism by baclofen.
Conduite à tenir
Reserve the combination for patients without adequate alternatives, using the lowest effective doses for the shortest duration. Monitor closely for sedation and respiratory depression, particularly at initiation and after dose increases.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Références
Autres interactions de Baclofen
- Alfentanil + Baclofen Majeure
- Amobarbital + Baclofen Majeure
- Baclofen + Belladonna and opium Majeure
- Baclofen + Brexanolone Majeure
- Baclofen + Buprenorphine buccal Majeure
- Baclofen + Buprenorphine long-acting Majeure
Questions fréquentes
Can I take Baclofen with Benzhydrocodone / acetaminophen?
MediHelp rates the interaction as major. Baclofen and Benzhydrocodone / acetaminophen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining baclofen with an opioid such as benzhydrocodone adds to central nervous system and respiratory depression. Profound sedation, respiratory depression, coma and death can occur, especially at higher doses or in vulnerable patients.
How serious is the interaction between Baclofen and Benzhydrocodone / acetaminophen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients without adequate alternatives, using the lowest effective doses for the shortest duration. Monitor closely for sedation and respiratory depression, particularly at initiation and after dose increases.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
