Interactions médicamenteuses
Baclofen + Buprenorphine long-acting
Gravité: Majeure
Baclofen and Buprenorphine long-acting: major interaction.
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Résumé
Baclofen with long-acting injectable buprenorphine can cause additive sedation and respiratory depression. The depot gives prolonged exposure, so the interaction cannot be quickly reversed by stopping the opioid.
Ce que signifie cette interaction, en termes simples
Baclofen and Buprenorphine long-acting can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive CNS and respiratory depression from opioid receptor partial agonism and GABA-B agonism.
Conduite à tenir
Use only when other treatments are inadequate, titrating baclofen to the lowest effective dose. Monitor for sedation and respiratory depression, particularly after baclofen initiation or increases.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Baclofen
- Alfentanil + Baclofen Majeure
- Amobarbital + Baclofen Majeure
- Baclofen + Belladonna and opium Majeure
- Baclofen + Benzhydrocodone / acetaminophen Majeure
- Baclofen + Brexanolone Majeure
- Baclofen + Buprenorphine buccal Majeure
Questions fréquentes
Can I take Baclofen with Buprenorphine long-acting?
MediHelp rates the interaction as major. Baclofen and Buprenorphine long-acting can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Baclofen with long-acting injectable buprenorphine can cause additive sedation and respiratory depression. The depot gives prolonged exposure, so the interaction cannot be quickly reversed by stopping the opioid.
How serious is the interaction between Baclofen and Buprenorphine long-acting?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when other treatments are inadequate, titrating baclofen to the lowest effective dose. Monitor for sedation and respiratory depression, particularly after baclofen initiation or increases.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
