Interactions médicamenteuses
Baclofen + Brexanolone
Gravité: Majeure
Baclofen and Brexanolone: major interaction.
Dernière mise à jour
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Résumé
Brexanolone infusion causes excessive sedation and sudden loss of consciousness in some patients. Baclofen adds CNS depressant effects, which may increase the likelihood or depth of these events.
Ce que signifie cette interaction, en termes simples
Baclofen and Brexanolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive CNS depression, with brexanolone acting as a positive GABA-A modulator and baclofen as a GABA-B agonist.
Conduite à tenir
Monitor continuously for sedation and hypoxia during the infusion as required by labeling, and consider reducing or holding baclofen during treatment. Interrupt the infusion if excessive sedation occurs.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Baclofen
- Alfentanil + Baclofen Majeure
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- Baclofen + Belladonna and opium Majeure
- Baclofen + Benzhydrocodone / acetaminophen Majeure
- Baclofen + Buprenorphine buccal Majeure
- Baclofen + Buprenorphine long-acting Majeure
Questions fréquentes
Can I take Baclofen with Brexanolone?
MediHelp rates the interaction as major. Baclofen and Brexanolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexanolone infusion causes excessive sedation and sudden loss of consciousness in some patients. Baclofen adds CNS depressant effects, which may increase the likelihood or depth of these events.
How serious is the interaction between Baclofen and Brexanolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor continuously for sedation and hypoxia during the infusion as required by labeling, and consider reducing or holding baclofen during treatment. Interrupt the infusion if excessive sedation occurs.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
