Interactions médicamenteuses
Balsalazide + Voclosporin
Gravité: Modérée
Balsalazide and Voclosporin: moderate interaction.
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Résumé
Voclosporin is a calcineurin inhibitor that is nephrotoxic. Mesalamine-type drugs such as balsalazide have rarely been associated with interstitial nephritis and renal impairment, so the renal risk may be additive.
Ce que signifie cette interaction, en termes simples
Balsalazide and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Balsalazide belongs to Gastrointestinal Tract; Voclosporin belongs to Miscellaneous.
Pourquoi elle survient
Additive nephrotoxic potential through different mechanisms (calcineurin inhibitor hemodynamic effect and mesalamine interstitial nephritis).
Conduite à tenir
Monitor serum creatinine and eGFR at baseline and regularly during combined use. Reduce the voclosporin dose or stop the agents if renal function declines.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Balsalazide
Autres interactions de Voclosporin
- Clarithromycin + Voclosporin Contre-indiquée
- Cyclosporin + Voclosporin Contre-indiquée
- Ensitrelvir + Voclosporin Contre-indiquée
- Itraconazole + Voclosporin Contre-indiquée
- Ketoconazole + Voclosporin Contre-indiquée
- Posaconazole + Voclosporin Contre-indiquée
Questions fréquentes
Can I take Balsalazide with Voclosporin?
MediHelp rates the interaction as moderate. Balsalazide and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin is a calcineurin inhibitor that is nephrotoxic. Mesalamine-type drugs such as balsalazide have rarely been associated with interstitial nephritis and renal impairment, so the renal risk may be additive.
How serious is the interaction between Balsalazide and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and eGFR at baseline and regularly during combined use. Reduce the voclosporin dose or stop the agents if renal function declines.
What other medicines interact with Balsalazide?
MediHelp also lists interactions of Balsalazide with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Balsalazide page.
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