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Interactions médicamenteuses

Cyclosporin + Voclosporin

Gravité: Contre-indiquée

Cyclosporin and Voclosporin: contraindicated interaction.

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Résumé

Both are calcineurin inhibitors, so combining them gives duplicate immunosuppression and additive nephrotoxicity, hyperkalemia and infection risk. Cyclosporine also inhibits CYP3A4 and raises voclosporin exposure.

Ce que signifie cette interaction, en termes simples

Cyclosporin and Voclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Cyclosporin belongs to Miscellaneous; Voclosporin belongs to Miscellaneous.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive calcineurin inhibition with pharmacodynamic overlap, plus cyclosporine-mediated CYP3A4 inhibition that increases voclosporin levels.

Conduite à tenir

Do not use the two calcineurin inhibitors together. Use only one agent and allow appropriate washout when switching.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cyclosporin with Voclosporin?

MediHelp rates the interaction as contraindicated. Cyclosporin and Voclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are calcineurin inhibitors, so combining them gives duplicate immunosuppression and additive nephrotoxicity, hyperkalemia and infection risk. Cyclosporine also inhibits CYP3A4 and raises voclosporin exposure.

How serious is the interaction between Cyclosporin and Voclosporin?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use the two calcineurin inhibitors together. Use only one agent and allow appropriate washout when switching.

What other medicines interact with Cyclosporin?

MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.

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