Interactions médicamenteuses
Bcg vaccine live + Methylprednisolone
Gravité: Contre-indiquée
Bcg vaccine live and Methylprednisolone: contraindicated interaction.
Dernière mise à jour
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Résumé
BCG is a live attenuated vaccine, and immunosuppressive doses of methylprednisolone can allow uncontrolled replication, causing disseminated BCG infection. The vaccine response may also be diminished.
Ce que signifie cette interaction, en termes simples
Bcg vaccine live and Methylprednisolone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Corticosteroid-induced impairment of cell-mediated immunity reduces control of live attenuated organisms.
Conduite à tenir
Do not give BCG to patients on immunosuppressive corticosteroid doses. Delay vaccination until the steroid has been stopped for the interval recommended in local guidance, typically at least one month.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Methylprednisolone
- Measles mumps and rubella vaccine live + Methylprednisolone Contre-indiquée
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contre-indiquée
- Measles vaccine + Methylprednisolone Contre-indiquée
- Methylprednisolone + Mifepristone Contre-indiquée
- Methylprednisolone + Rubella vaccine Contre-indiquée
- Methylprednisolone + Smallpox vaccine live Contre-indiquée
Questions fréquentes
Can I take Bcg vaccine live with Methylprednisolone?
MediHelp rates the interaction as contraindicated. Bcg vaccine live and Methylprednisolone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. BCG is a live attenuated vaccine, and immunosuppressive doses of methylprednisolone can allow uncontrolled replication, causing disseminated BCG infection. The vaccine response may also be diminished.
How serious is the interaction between Bcg vaccine live and Methylprednisolone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give BCG to patients on immunosuppressive corticosteroid doses. Delay vaccination until the steroid has been stopped for the interval recommended in local guidance, typically at least one month.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live, Measles vaccine. The full list is on the Methylprednisolone page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
