Interactions médicamenteuses
Methylprednisolone + Smallpox vaccine live
Gravité: Contre-indiquée
Methylprednisolone and Smallpox vaccine live: contraindicated interaction.
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Résumé
Live vaccinia vaccine can cause progressive vaccinia and generalized infection in immunosuppressed patients, including those on corticosteroids. The vaccine response may also be reduced.
Ce que signifie cette interaction, en termes simples
Methylprednisolone and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Corticosteroid-induced immunosuppression allows uncontrolled replication of live vaccinia virus.
Conduite à tenir
Avoid live smallpox vaccine in patients on immunosuppressive steroids outside an emergency. If exposure risk is high, use a non-replicating vaccine where available and obtain specialist advice.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contre-indiquée
- Measles mumps and rubella vaccine live + Methylprednisolone Contre-indiquée
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contre-indiquée
- Measles vaccine + Methylprednisolone Contre-indiquée
- Methylprednisolone + Mifepristone Contre-indiquée
- Methylprednisolone + Rubella vaccine Contre-indiquée
Questions fréquentes
Can I take Methylprednisolone with Smallpox vaccine live?
MediHelp rates the interaction as contraindicated. Methylprednisolone and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live vaccinia vaccine can cause progressive vaccinia and generalized infection in immunosuppressed patients, including those on corticosteroids. The vaccine response may also be reduced.
How serious is the interaction between Methylprednisolone and Smallpox vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live smallpox vaccine in patients on immunosuppressive steroids outside an emergency. If exposure risk is high, use a non-replicating vaccine where available and obtain specialist advice.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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