Interactions médicamenteuses
Belladonna and opium + Oxazepam
Gravité: Majeure
Belladonna and opium and Oxazepam: major interaction.
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Résumé
Opium contains opioids that, together with a benzodiazepine, can produce profound sedation, respiratory depression, coma and death. Belladonna anticholinergic effects may further add to confusion and CNS effects.
Ce que signifie cette interaction, en termes simples
Belladonna and opium and Oxazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive CNS and respiratory depression from opioid receptor agonism and GABA-A potentiation.
Conduite à tenir
Avoid combining where possible; if necessary use the lowest doses for the shortest duration. Monitor respiratory rate and sedation closely and consider naloxone availability.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contre-indiquée
- Oxazepam + Sodium oxybate Contre-indiquée
- Alfentanil + Oxazepam Majeure
- Amobarbital + Oxazepam Majeure
- Baclofen + Oxazepam Majeure
- Benzhydrocodone / acetaminophen + Oxazepam Majeure
Questions fréquentes
Can I take Belladonna and opium with Oxazepam?
MediHelp rates the interaction as major. Belladonna and opium and Oxazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opium contains opioids that, together with a benzodiazepine, can produce profound sedation, respiratory depression, coma and death. Belladonna anticholinergic effects may further add to confusion and CNS effects.
How serious is the interaction between Belladonna and opium and Oxazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if necessary use the lowest doses for the shortest duration. Monitor respiratory rate and sedation closely and consider naloxone availability.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
