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Interactions médicamenteuses

Amobarbital + Oxazepam

Gravité: Majeure

Amobarbital and Oxazepam: major interaction.

Dernière mise à jour

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Résumé

Barbiturates and benzodiazepines together produce profound additive CNS and respiratory depression. Risk includes excessive sedation, hypotension, coma and death, particularly with parenteral amobarbital.

Ce que signifie cette interaction, en termes simples

Amobarbital and Oxazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amobarbital belongs to Central Nervous System; Oxazepam belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Both enhance GABA-A receptor activity at different sites, producing additive CNS and respiratory depression.

Conduite à tenir

Avoid combining where possible; if required, reduce doses and monitor respiratory rate, oxygen saturation and level of consciousness closely.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amobarbital with Oxazepam?

MediHelp rates the interaction as major. Amobarbital and Oxazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates and benzodiazepines together produce profound additive CNS and respiratory depression. Risk includes excessive sedation, hypotension, coma and death, particularly with parenteral amobarbital.

How serious is the interaction between Amobarbital and Oxazepam?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if required, reduce doses and monitor respiratory rate, oxygen saturation and level of consciousness closely.

What other medicines interact with Oxazepam?

MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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