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Interactions médicamenteuses

Oxazepam + Sodium oxybate

Gravité: Contre-indiquée

Oxazepam and Sodium oxybate: contraindicated interaction.

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Résumé

Sodium oxybate combined with a benzodiazepine causes additive CNS and respiratory depression, with risk of profound sedation, coma, and death. Labeling prohibits concomitant use with sedative hypnotics.

Ce que signifie cette interaction, en termes simples

Oxazepam and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Oxazepam belongs to Central Nervous System; Sodium oxybate belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Additive CNS depression via GABA-B agonism by oxybate and GABA-A potentiation by oxazepam.

Conduite à tenir

Avoid the combination; choose an alternative to one of the agents. If unavoidable, monitor respiratory status closely.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Oxazepam with Sodium oxybate?

MediHelp rates the interaction as contraindicated. Oxazepam and Sodium oxybate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sodium oxybate combined with a benzodiazepine causes additive CNS and respiratory depression, with risk of profound sedation, coma, and death. Labeling prohibits concomitant use with sedative hypnotics.

How serious is the interaction between Oxazepam and Sodium oxybate?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; choose an alternative to one of the agents. If unavoidable, monitor respiratory status closely.

What other medicines interact with Oxazepam?

MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Amobarbital. The full list is on the Oxazepam page.

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