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Interactions médicamenteuses

Benazepril + Hydrochlorothiazide-irbesartan

Gravité: Majeure

Benazepril and Hydrochlorothiazide-irbesartan: major interaction.

Dernière mise à jour

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Résumé

Combining an angiotensin receptor blocker with an ACE inhibitor produces dual renin-angiotensin system blockade. This raises the risk of symptomatic hypotension, hyperkalemia and acute kidney injury without a meaningful gain in cardiovascular outcomes.

Ce que signifie cette interaction, en termes simples

Benazepril and Hydrochlorothiazide-irbesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Benazepril belongs to Cardiovascular; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Additive pharmacodynamic suppression of angiotensin II activity at two points of the renin-angiotensin system reduces glomerular filtration pressure and aldosterone-mediated potassium excretion.

Conduite à tenir

Avoid the combination in routine practice and choose a single renin-angiotensin agent. If it is used for a specific indication, monitor blood pressure, serum potassium and creatinine closely.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Benazepril with Hydrochlorothiazide-irbesartan?

MediHelp rates the interaction as major. Benazepril and Hydrochlorothiazide-irbesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an angiotensin receptor blocker with an ACE inhibitor produces dual renin-angiotensin system blockade. This raises the risk of symptomatic hypotension, hyperkalemia and acute kidney injury without a meaningful gain in cardiovascular outcomes.

How serious is the interaction between Benazepril and Hydrochlorothiazide-irbesartan?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in routine practice and choose a single renin-angiotensin agent. If it is used for a specific indication, monitor blood pressure, serum potassium and creatinine closely.

What other medicines interact with Hydrochlorothiazide-irbesartan?

MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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