Interactions médicamenteuses
Bortezomib + Idelalisib
Gravité: Majeure
Bortezomib and Idelalisib: major interaction.
Dernière mise à jour Sources: US FDA label
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Idelalisib is a strong CYP3A inhibitor, and bortezomib is partly cleared by CYP3A4. Strong inhibitors such as ketoconazole have increased bortezomib exposure, so toxicity such as neuropathy and thrombocytopenia may rise. Idelalisib also carries risks of serious infection and diarrhea.
Ce que signifie cette interaction, en termes simples
Bortezomib and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bortezomib belongs to Oncology; Idelalisib belongs to Oncology.
Pourquoi elle survient
Idelalisib inhibits CYP3A4, reducing bortezomib clearance.
Conduite à tenir
Monitor closely for neuropathy, cytopenias and infection, and consider a bortezomib dose reduction. Choose an alternative to idelalisib if possible.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Bortezomib et Idelalisib, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 7 jours sur le web. Sans carte.
Références
Autres interactions de Bortezomib
- Apalutamide + Bortezomib Majeure
- Bortezomib + Carbamazepine Majeure
- Bortezomib + Etrasimod Majeure
- Bortezomib + Fosphenytoin Majeure
- Bortezomib + Lonafarnib Majeure
- Bortezomib + Mitotane Majeure
Autres interactions de Idelalisib
- Alfuzosin + Idelalisib Contre-indiquée
- Cisapride + Idelalisib Contre-indiquée
- Dihydroergotamine + Idelalisib Contre-indiquée
- Dronedarone + Idelalisib Contre-indiquée
- Eletriptan + Idelalisib Contre-indiquée
- Eplerenone + Idelalisib Contre-indiquée
Questions fréquentes
Can I take Bortezomib with Idelalisib?
MediHelp rates the interaction as major. Bortezomib and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor, and bortezomib is partly cleared by CYP3A4. Strong inhibitors such as ketoconazole have increased bortezomib exposure, so toxicity such as neuropathy and thrombocytopenia may rise. Idelalisib also carries risks of serious infection and diarrhea.
How serious is the interaction between Bortezomib and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for neuropathy, cytopenias and infection, and consider a bortezomib dose reduction. Choose an alternative to idelalisib if possible.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
