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Interactions médicamenteuses

Eletriptan + Idelalisib

Gravité: Contre-indiquée

Eletriptan and Idelalisib: contraindicated interaction.

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Résumé

Idelalisib is a strong CYP3A inhibitor and markedly increases exposure to CYP3A4 substrates. Eletriptan is labeled as contraindicated with strong CYP3A4 inhibitors within at least 72 hours because of the risk of higher exposure and vasoconstrictive adverse effects.

Ce que signifie cette interaction, en termes simples

Eletriptan and Idelalisib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Eletriptan belongs to Central Nervous System; Idelalisib belongs to Oncology.

Niveau de preuve: High

Pourquoi elle survient

Strong CYP3A4 inhibition by idelalisib reduces eletriptan first-pass and systemic clearance.

Conduite à tenir

Do not use eletriptan with idelalisib. Choose a triptan not metabolized by CYP3A4.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Eletriptan with Idelalisib?

MediHelp rates the interaction as contraindicated. Eletriptan and Idelalisib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Idelalisib is a strong CYP3A inhibitor and markedly increases exposure to CYP3A4 substrates. Eletriptan is labeled as contraindicated with strong CYP3A4 inhibitors within at least 72 hours because of the risk of higher exposure and vasoconstrictive adverse effects.

How serious is the interaction between Eletriptan and Idelalisib?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use eletriptan with idelalisib. Choose a triptan not metabolized by CYP3A4.

What other medicines interact with Eletriptan?

MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.

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