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Interactions médicamenteuses

Bortezomib + Lonafarnib

Gravité: Majeure

Bortezomib and Lonafarnib: major interaction.

Dernière mise à jour Sources: US FDA label

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Résumé

Lonafarnib is a strong CYP3A inhibitor and may increase bortezomib exposure, worsening neuropathy and cytopenias. Lonafarnib is itself a sensitive CYP3A substrate, so inhibition by bortezomib is unlikely to be clinically relevant. Lonafarnib's QT effect is also unknown.

Ce que signifie cette interaction, en termes simples

Bortezomib and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Bortezomib belongs to Oncology; Lonafarnib belongs to Miscellaneous.

Niveau de preuve: Low

Pourquoi elle survient

Lonafarnib inhibits CYP3A4, decreasing bortezomib clearance.

Conduite à tenir

Avoid if possible; otherwise monitor for neuropathy, thrombocytopenia and arrhythmia symptoms, and consider reducing the bortezomib dose.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Bortezomib with Lonafarnib?

MediHelp rates the interaction as major. Bortezomib and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lonafarnib is a strong CYP3A inhibitor and may increase bortezomib exposure, worsening neuropathy and cytopenias. Lonafarnib is itself a sensitive CYP3A substrate, so inhibition by bortezomib is unlikely to be clinically relevant. Lonafarnib's QT effect is also unknown.

How serious is the interaction between Bortezomib and Lonafarnib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor for neuropathy, thrombocytopenia and arrhythmia symptoms, and consider reducing the bortezomib dose.

What other medicines interact with Bortezomib?

MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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