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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Brigatinib + Efavirenz

Gravité: Majeure

Brigatinib and Efavirenz: major interaction.

Dernière mise à jour

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Résumé

Efavirenz can lower brigatinib exposure through CYP3A induction, potentially reducing its anti-tumor effect in ALK-positive lung cancer.

Ce que signifie cette interaction, en termes simples

Brigatinib and Efavirenz can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Brigatinib belongs to Oncology; Efavirenz belongs to Anti Virals.

Niveau de preuve: Moderate

Pourquoi elle survient

Efavirenz induces CYP3A4, accelerating brigatinib metabolism.

Conduite à tenir

Avoid the combination and use a non-inducing antiretroviral. If a strong or moderate inducer is unavoidable, the brigatinib dose may need to be increased per labeling with close monitoring of response and tolerability.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Brigatinib with Efavirenz?

MediHelp rates the interaction as major. Brigatinib and Efavirenz can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Efavirenz can lower brigatinib exposure through CYP3A induction, potentially reducing its anti-tumor effect in ALK-positive lung cancer.

How serious is the interaction between Brigatinib and Efavirenz?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing antiretroviral. If a strong or moderate inducer is unavoidable, the brigatinib dose may need to be increased per labeling with close monitoring of response and tolerability.

What other medicines interact with Efavirenz?

MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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