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Interactions médicamenteuses

Brigatinib + Enzalutamide

Gravité: Majeure

Brigatinib and Enzalutamide: major interaction.

Dernière mise à jour

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Résumé

Enzalutamide reduces brigatinib exposure through enzyme induction. Reduced exposure may compromise control of ALK-positive lung cancer.

Ce que signifie cette interaction, en termes simples

Brigatinib and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Brigatinib belongs to Oncology; Enzalutamide belongs to Endocrine.

Niveau de preuve: High

Pourquoi elle survient

CYP3A4 induction by enzalutamide increases brigatinib clearance.

Conduite à tenir

Avoid concurrent use. If a strong inducer cannot be avoided, brigatinib labeling advises increasing the dose in stepwise fashion and reducing it again after the inducer is stopped.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Brigatinib with Enzalutamide?

MediHelp rates the interaction as major. Brigatinib and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide reduces brigatinib exposure through enzyme induction. Reduced exposure may compromise control of ALK-positive lung cancer.

How serious is the interaction between Brigatinib and Enzalutamide?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. If a strong inducer cannot be avoided, brigatinib labeling advises increasing the dose in stepwise fashion and reducing it again after the inducer is stopped.

What other medicines interact with Enzalutamide?

MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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