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Interactions médicamenteuses

Brigatinib + Clarithromycin

Gravité: Majeure

Brigatinib and Clarithromycin: major interaction.

Dernière mise à jour

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Résumé

Clarithromycin raises brigatinib exposure through strong CYP3A inhibition, increasing risk of adverse effects such as pulmonary toxicity, hypertension, bradycardia and pancreatic enzyme elevations.

Ce que signifie cette interaction, en termes simples

Brigatinib and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Brigatinib belongs to Oncology; Clarithromycin belongs to Anti Bacterial.

Niveau de preuve: High

Pourquoi elle survient

Inhibition of CYP3A4-mediated metabolism of brigatinib.

Conduite à tenir

Avoid if possible. If unavoidable, reduce brigatinib dose by about half and resume the prior dose after stopping clarithromycin.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Brigatinib with Clarithromycin?

MediHelp rates the interaction as major. Brigatinib and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin raises brigatinib exposure through strong CYP3A inhibition, increasing risk of adverse effects such as pulmonary toxicity, hypertension, bradycardia and pancreatic enzyme elevations.

How serious is the interaction between Brigatinib and Clarithromycin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, reduce brigatinib dose by about half and resume the prior dose after stopping clarithromycin.

What other medicines interact with Clarithromycin?

MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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