Interactions médicamenteuses
Buprenorphine long-acting + Tranylcypromine
Gravité: Contre-indiquée
Buprenorphine long-acting and Tranylcypromine: contraindicated interaction.
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Résumé
Combining an MAOI with an opioid like buprenorphine can cause serotonin syndrome, and may also produce opioid toxicity with respiratory depression and coma. Because the long-acting injection cannot be quickly removed, any reaction can be prolonged.
Ce que signifie cette interaction, en termes simples
Buprenorphine long-acting and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Serotonergic excess from MAO inhibition combined with opioid effects, plus possible enhancement of opioid CNS and respiratory depression.
Conduite à tenir
Do not use the long-acting injection in patients taking an MAOI or within 14 days of stopping one. Choose a non-serotonergic alternative or wait the washout period.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Tranylcypromine
- 5-HTP + Tranylcypromine Contre-indiquée
- Amitriptyline + Tranylcypromine Contre-indiquée
- Amoxapine + Tranylcypromine Contre-indiquée
- Atomoxetine + Tranylcypromine Contre-indiquée
- Benzphetamine + Tranylcypromine Contre-indiquée
- Brimonidine + Tranylcypromine Contre-indiquée
Questions fréquentes
Can I take Buprenorphine long-acting with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Buprenorphine long-acting and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an MAOI with an opioid like buprenorphine can cause serotonin syndrome, and may also produce opioid toxicity with respiratory depression and coma. Because the long-acting injection cannot be quickly removed, any reaction can be prolonged.
How serious is the interaction between Buprenorphine long-acting and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use the long-acting injection in patients taking an MAOI or within 14 days of stopping one. Choose a non-serotonergic alternative or wait the washout period.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
