Interactions médicamenteuses
Amoxapine + Tranylcypromine
Gravité: Contre-indiquée
Amoxapine and Tranylcypromine: contraindicated interaction.
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Résumé
Amoxapine blocks reuptake of norepinephrine and serotonin, and tranylcypromine is an irreversible nonselective MAOI. Together they can cause serotonin syndrome or hypertensive crisis.
Ce que signifie cette interaction, en termes simples
Amoxapine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Reuptake inhibition combined with irreversible MAO inhibition increases synaptic serotonin and norepinephrine.
Conduite à tenir
Do not combine. Observe a washout of at least 14 days after stopping tranylcypromine before starting amoxapine, and an adequate washout of amoxapine before starting an MAOI.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Tranylcypromine
- 5-HTP + Tranylcypromine Contre-indiquée
- Amitriptyline + Tranylcypromine Contre-indiquée
- Atomoxetine + Tranylcypromine Contre-indiquée
- Benzphetamine + Tranylcypromine Contre-indiquée
- Brimonidine + Tranylcypromine Contre-indiquée
- Buprenorphine long-acting + Tranylcypromine Contre-indiquée
Questions fréquentes
Can I take Amoxapine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Amoxapine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Amoxapine blocks reuptake of norepinephrine and serotonin, and tranylcypromine is an irreversible nonselective MAOI. Together they can cause serotonin syndrome or hypertensive crisis.
How serious is the interaction between Amoxapine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Observe a washout of at least 14 days after stopping tranylcypromine before starting amoxapine, and an adequate washout of amoxapine before starting an MAOI.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Atomoxetine. The full list is on the Tranylcypromine page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
