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Interactions médicamenteuses

Cabozantinib + Phenytoin

Gravité: Majeure

Cabozantinib and Phenytoin: major interaction.

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Résumé

Phenytoin lowers cabozantinib exposure through CYP3A4 induction, which may reduce anticancer efficacy.

Ce que signifie cette interaction, en termes simples

Cabozantinib and Phenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cabozantinib belongs to Oncology; Phenytoin belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Induction of CYP3A4 by phenytoin increases cabozantinib clearance.

Conduite à tenir

Avoid the combination where possible and use a non-inducing antiepileptic. If unavoidable, raise the cabozantinib dose per product labeling and return to the usual dose a few days after stopping phenytoin.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cabozantinib with Phenytoin?

MediHelp rates the interaction as major. Cabozantinib and Phenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenytoin lowers cabozantinib exposure through CYP3A4 induction, which may reduce anticancer efficacy.

How serious is the interaction between Cabozantinib and Phenytoin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use a non-inducing antiepileptic. If unavoidable, raise the cabozantinib dose per product labeling and return to the usual dose a few days after stopping phenytoin.

What other medicines interact with Phenytoin?

MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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