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Interactions médicamenteuses

Cannabidiol + Dronabinol

Gravité: Modérée

Cannabidiol and Dronabinol: moderate interaction.

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Résumé

Cannabidiol inhibits CYP2C9 and CYP3A4 and may raise dronabinol (THC) concentrations, increasing psychoactive effects such as sedation, dizziness and tachycardia. Both agents also have additive CNS effects.

Ce que signifie cette interaction, en termes simples

Cannabidiol and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cannabidiol belongs to Central Nervous System; Dronabinol belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Cannabidiol inhibits CYP2C9 and CYP3A4 metabolism of dronabinol, plus additive CNS effects.

Conduite à tenir

Monitor for excessive sedation, cognitive impairment and tachycardia; reduce the dronabinol dose if adverse effects appear.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cannabidiol with Dronabinol?

MediHelp rates the interaction as moderate. Cannabidiol and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol inhibits CYP2C9 and CYP3A4 and may raise dronabinol (THC) concentrations, increasing psychoactive effects such as sedation, dizziness and tachycardia. Both agents also have additive CNS effects.

How serious is the interaction between Cannabidiol and Dronabinol?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, cognitive impairment and tachycardia; reduce the dronabinol dose if adverse effects appear.

What other medicines interact with Dronabinol?

MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Disulfiram, Midazolam intranasal. The full list is on the Dronabinol page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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