Interactions médicamenteuses
Cannabidiol + Sodium valproate
Gravité: Majeure
Cannabidiol and Sodium valproate: major interaction.
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Résumé
Concurrent use increases the incidence of raised liver transaminases compared with either drug alone. Cases of significant hepatotoxicity may occur.
Ce que signifie cette interaction, en termes simples
Cannabidiol and Sodium valproate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cannabidiol belongs to Central Nervous System; Sodium valproate belongs to Central Nervous System.
Pourquoi elle survient
Probably additive hepatotoxicity; the exact mechanism is not established.
Conduite à tenir
Check liver enzymes and bilirubin before treatment and periodically thereafter. Reduce or stop one or both drugs if transaminases rise significantly.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Cannabidiol
- Cannabidiol + Phenytoin Majeure
- Cannabidiol + Tacrolimus Majeure
- Abiraterone + Cannabidiol Modérée
- Alogliptin-pioglitazone + Cannabidiol Modérée
- Amiodarone + Cannabidiol Modérée
- Amobarbital + Cannabidiol Modérée
Autres interactions de Sodium valproate
Questions fréquentes
Can I take Cannabidiol with Sodium valproate?
MediHelp rates the interaction as major. Cannabidiol and Sodium valproate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent use increases the incidence of raised liver transaminases compared with either drug alone. Cases of significant hepatotoxicity may occur.
How serious is the interaction between Cannabidiol and Sodium valproate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check liver enzymes and bilirubin before treatment and periodically thereafter. Reduce or stop one or both drugs if transaminases rise significantly.
What other medicines interact with Cannabidiol?
MediHelp also lists interactions of Cannabidiol with, for example, Phenytoin, Tacrolimus, Abiraterone. The full list is on the Cannabidiol page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
