Drug interactions
Cannabidiol + Dronabinol
Severity: Moderate
Cannabidiol and Dronabinol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol inhibits CYP2C9 and CYP3A4 and may raise dronabinol (THC) concentrations, increasing psychoactive effects such as sedation, dizziness and tachycardia. Both agents also have additive CNS effects.
What this interaction means in plain words
Cannabidiol and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Dronabinol belongs to Central Nervous System.
Why it happens
Cannabidiol inhibits CYP2C9 and CYP3A4 metabolism of dronabinol, plus additive CNS effects.
What to do
Monitor for excessive sedation, cognitive impairment and tachycardia; reduce the dronabinol dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Dronabinol?
MediHelp rates the interaction as moderate. Cannabidiol and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol inhibits CYP2C9 and CYP3A4 and may raise dronabinol (THC) concentrations, increasing psychoactive effects such as sedation, dizziness and tachycardia. Both agents also have additive CNS effects.
How serious is the interaction between Cannabidiol and Dronabinol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, cognitive impairment and tachycardia; reduce the dronabinol dose if adverse effects appear.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Disulfiram, Midazolam intranasal. The full list is on the Dronabinol page.
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