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Interactions médicamenteuses

Glycerol phenylbutyrate + Sodium valproate

Gravité: Majeure

Glycerol phenylbutyrate and Sodium valproate: major interaction.

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Résumé

Valproate can cause hyperammonemia and may antagonize the ammonia-lowering effect of glycerol phenylbutyrate in patients with urea cycle disorders. This may precipitate hyperammonemic crises.

Ce que signifie cette interaction, en termes simples

Glycerol phenylbutyrate and Sodium valproate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Glycerol phenylbutyrate belongs to Miscellaneous; Sodium valproate belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Valproate inhibits urea cycle enzyme function (e.g., via carnitine and N-acetylglutamate depletion), raising ammonia.

Conduite à tenir

Avoid valproate in urea cycle disorders where possible. If used, monitor plasma ammonia closely and adjust the glycerol phenylbutyrate dose.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Glycerol phenylbutyrate with Sodium valproate?

MediHelp rates the interaction as major. Glycerol phenylbutyrate and Sodium valproate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Valproate can cause hyperammonemia and may antagonize the ammonia-lowering effect of glycerol phenylbutyrate in patients with urea cycle disorders. This may precipitate hyperammonemic crises.

How serious is the interaction between Glycerol phenylbutyrate and Sodium valproate?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid valproate in urea cycle disorders where possible. If used, monitor plasma ammonia closely and adjust the glycerol phenylbutyrate dose.

What other medicines interact with Glycerol phenylbutyrate?

MediHelp also lists interactions of Glycerol phenylbutyrate with, for example, Dexamethasone, Valproic acid, Cyclosporin. The full list is on the Glycerol phenylbutyrate page.

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