Interactions médicamenteuses
Clozapine + Deferiprone
Gravité: Contre-indiquée
Clozapine and Deferiprone: contraindicated interaction.
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Résumé
Both drugs can cause severe neutropenia and agranulocytosis, and using them together may compound the risk. Deferiprone labeling advises against its use with other drugs known to cause neutropenia.
Ce que signifie cette interaction, en termes simples
Clozapine and Deferiprone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clozapine belongs to Central Nervous System; Deferiprone belongs to Miscellaneous.
Pourquoi elle survient
Additive bone marrow suppression and risk of agranulocytosis.
Conduite à tenir
Avoid concurrent use and choose an alternative iron chelator or antipsychotic. If unavoidable, monitor the absolute neutrophil count very frequently and stop at the first sign of neutropenia.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Clozapine
- Clozapine + Irinotecan Contre-indiquée
- Clozapine + Pimozide Contre-indiquée
- Clozapine + Thioridazine Contre-indiquée
- Acalabrutinib + Clozapine Majeure
- Adagrasib + Clozapine Majeure
- Adrenaline-articaine + Clozapine Majeure
Autres interactions de Deferiprone
- Abemaciclib + Deferiprone Majeure
- Acalabrutinib + Deferiprone Majeure
- Ado-trastuzumab emtansine + Deferiprone Majeure
- Ado-trastuzumab + Deferiprone Majeure
- Aldesleukin + Deferiprone Majeure
- Baricitinib + Deferiprone Majeure
Questions fréquentes
Can I take Clozapine with Deferiprone?
MediHelp rates the interaction as contraindicated. Clozapine and Deferiprone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can cause severe neutropenia and agranulocytosis, and using them together may compound the risk. Deferiprone labeling advises against its use with other drugs known to cause neutropenia.
How serious is the interaction between Clozapine and Deferiprone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose an alternative iron chelator or antipsychotic. If unavoidable, monitor the absolute neutrophil count very frequently and stop at the first sign of neutropenia.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Irinotecan, Pimozide, Thioridazine. The full list is on the Clozapine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
