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Interactions médicamenteuses

Carbamazepine + Lorlatinib

Gravité: Contre-indiquée

Carbamazepine and Lorlatinib: contraindicated interaction.

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Résumé

Carbamazepine is a strong inducer of CYP3A4, CYP2B6, CYP1A2 and P-glycoprotein and accelerates the clearance of lorlatinib. The result is reduced lorlatinib exposure and loss of tumour control; strong inducers have also provoked marked transaminase elevation.

Ce que signifie cette interaction, en termes simples

Carbamazepine and Lorlatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Carbamazepine belongs to Central Nervous System; Lorlatinib belongs to Oncology.

Niveau de preuve: High

Pourquoi elle survient

Enzyme induction by carbamazepine increases metabolic clearance of lorlatinib

Conduite à tenir

Do not co-administer; use a non-inducing alternative to carbamazepine, and allow enzyme induction to wane (several weeks) before starting lorlatinib.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Carbamazepine with Lorlatinib?

MediHelp rates the interaction as contraindicated. Carbamazepine and Lorlatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine is a strong inducer of CYP3A4, CYP2B6, CYP1A2 and P-glycoprotein and accelerates the clearance of lorlatinib. The result is reduced lorlatinib exposure and loss of tumour control; strong inducers have also provoked marked transaminase elevation.

How serious is the interaction between Carbamazepine and Lorlatinib?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-inducing alternative to carbamazepine, and allow enzyme induction to wane (several weeks) before starting lorlatinib.

What other medicines interact with Carbamazepine?

MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.

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