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Interactions médicamenteuses

Lonafarnib + Lorlatinib

Gravité: Contre-indiquée

Lonafarnib and Lorlatinib: contraindicated interaction.

Dernière mise à jour

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Résumé

Lorlatinib induces CYP3A4, and lonafarnib is a sensitive CYP3A4 substrate. Lowered lonafarnib exposure may reduce its benefit, and labeling contraindicates its use with CYP3A inducers.

Ce que signifie cette interaction, en termes simples

Lonafarnib and Lorlatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Lonafarnib belongs to Miscellaneous; Lorlatinib belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Lorlatinib induces CYP3A4 and speeds lonafarnib metabolism.

Conduite à tenir

Avoid the combination and consider an alternative to lorlatinib. Seek specialist advice if both are essential.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Lonafarnib with Lorlatinib?

MediHelp rates the interaction as contraindicated. Lonafarnib and Lorlatinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lorlatinib induces CYP3A4, and lonafarnib is a sensitive CYP3A4 substrate. Lowered lonafarnib exposure may reduce its benefit, and labeling contraindicates its use with CYP3A inducers.

How serious is the interaction between Lonafarnib and Lorlatinib?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and consider an alternative to lorlatinib. Seek specialist advice if both are essential.

What other medicines interact with Lorlatinib?

MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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