Interactions médicamenteuses
Carbidopa-entacapone-levodopa + Sapropterin
Gravité: Modérée
Carbidopa-entacapone-levodopa and Sapropterin: moderate interaction.
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Résumé
Sapropterin is a cofactor for tyrosine hydroxylase and nitric oxide synthase, and combined use with levodopa has been associated with reports of convulsions, overstimulation and irritability. Labeling advises caution, though evidence is limited.
Ce que signifie cette interaction, en termes simples
Carbidopa-entacapone-levodopa and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Sapropterin belongs to Miscellaneous.
Pourquoi elle survient
Not firmly established; possibly enhanced dopaminergic and nitric oxide pathway activity.
Conduite à tenir
Monitor for agitation, irritability and seizures after starting sapropterin and reduce doses if these occur.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contre-indiquée
- Carbidopa-entacapone-levodopa + Phenelzine Contre-indiquée
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contre-indiquée
- Carbidopa-entacapone-levodopa + Tranylcypromine Contre-indiquée
- Amisulpride + Carbidopa-entacapone-levodopa Majeure
- Asenapine transdermal + Carbidopa-entacapone-levodopa Majeure
Autres interactions de Sapropterin
- Avanafil + Sapropterin Modérée
- Carbidopa-levodopa + Sapropterin Modérée
- Levodopa + Sapropterin Modérée
- Methotrexate + Sapropterin Modérée
- Phenobarbitone + Sapropterin Modérée
- Pyrimethamine + Sapropterin Modérée
Questions fréquentes
Can I take Carbidopa-entacapone-levodopa with Sapropterin?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sapropterin is a cofactor for tyrosine hydroxylase and nitric oxide synthase, and combined use with levodopa has been associated with reports of convulsions, overstimulation and irritability. Labeling advises caution, though evidence is limited.
How serious is the interaction between Carbidopa-entacapone-levodopa and Sapropterin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, irritability and seizures after starting sapropterin and reduce doses if these occur.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
