Interactions médicamenteuses
Carbidopa-entacapone-levodopa + Tranylcypromine
Gravité: Contre-indiquée
Carbidopa-entacapone-levodopa and Tranylcypromine: contraindicated interaction.
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Résumé
Levodopa is converted to dopamine and noradrenaline, and a non-selective MAO inhibitor (tranylcypromine) prevents their breakdown so the amines accumulate. Entacapone further impairs catecholamine breakdown through COMT inhibition. Severe hypertension, flushing, headache and hyperpyrexia may follow.
Ce que signifie cette interaction, en termes simples
Carbidopa-entacapone-levodopa and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Pourquoi elle survient
Non-selective MAO inhibition prevents degradation of levodopa-derived catecholamines with additional COMT inhibition
Conduite à tenir
Do not give together. Wait at least 14 days after stopping tranylcypromine before starting the other drug; carbidopa reduces but does not eliminate the risk.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contre-indiquée
- Carbidopa-entacapone-levodopa + Phenelzine Contre-indiquée
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contre-indiquée
- Amisulpride + Carbidopa-entacapone-levodopa Majeure
- Asenapine transdermal + Carbidopa-entacapone-levodopa Majeure
- Carbidopa-entacapone-levodopa + Chlorpromazine Majeure
Autres interactions de Tranylcypromine
- 5-HTP + Tranylcypromine Contre-indiquée
- Amitriptyline + Tranylcypromine Contre-indiquée
- Amoxapine + Tranylcypromine Contre-indiquée
- Atomoxetine + Tranylcypromine Contre-indiquée
- Benzphetamine + Tranylcypromine Contre-indiquée
- Brimonidine + Tranylcypromine Contre-indiquée
Questions fréquentes
Can I take Carbidopa-entacapone-levodopa with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Carbidopa-entacapone-levodopa and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa is converted to dopamine and noradrenaline, and a non-selective MAO inhibitor (tranylcypromine) prevents their breakdown so the amines accumulate. Entacapone further impairs catecholamine breakdown through COMT inhibition. Severe hypertension, flushing, headache and hyperpyrexia may follow.
How serious is the interaction between Carbidopa-entacapone-levodopa and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give together. Wait at least 14 days after stopping tranylcypromine before starting the other drug; carbidopa reduces but does not eliminate the risk.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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