Interactions médicamenteuses
Pyrimethamine + Sapropterin
Gravité: Modérée
Pyrimethamine and Sapropterin: moderate interaction.
Dernière mise à jour
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Résumé
Sapropterin is a synthetic form of tetrahydrobiopterin, and its recycling depends on folate-related enzymes. Pyrimethamine inhibits dihydrofolate reductase, which is also involved in pterin metabolism, so sapropterin effect may be reduced. The clinical significance is uncertain.
Ce que signifie cette interaction, en termes simples
Pyrimethamine and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pyrimethamine belongs to Anti Parasitic; Sapropterin belongs to Miscellaneous.
Pourquoi elle survient
Pyrimethamine, a DHFR inhibitor, may impair regeneration of tetrahydrobiopterin and so lessen sapropterin effect.
Conduite à tenir
Monitor blood phenylalanine more often when the two are combined, and adjust the sapropterin dose if control worsens.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Pyrimethamine
- Deferiprone + Pyrimethamine Majeure
- Eliglustat + Pyrimethamine Majeure
- Acalabrutinib + Pyrimethamine Modérée
- Brexpiprazole + Pyrimethamine Modérée
- Dapsone + Pyrimethamine Modérée
- Folic acid + Pyrimethamine Modérée
Autres interactions de Sapropterin
- Avanafil + Sapropterin Modérée
- Carbidopa-entacapone-levodopa + Sapropterin Modérée
- Carbidopa-levodopa + Sapropterin Modérée
- Levodopa + Sapropterin Modérée
- Methotrexate + Sapropterin Modérée
- Phenobarbitone + Sapropterin Modérée
Questions fréquentes
Can I take Pyrimethamine with Sapropterin?
MediHelp rates the interaction as moderate. Pyrimethamine and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sapropterin is a synthetic form of tetrahydrobiopterin, and its recycling depends on folate-related enzymes. Pyrimethamine inhibits dihydrofolate reductase, which is also involved in pterin metabolism, so sapropterin effect may be reduced. The clinical significance is uncertain.
How serious is the interaction between Pyrimethamine and Sapropterin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood phenylalanine more often when the two are combined, and adjust the sapropterin dose if control worsens.
What other medicines interact with Pyrimethamine?
MediHelp also lists interactions of Pyrimethamine with, for example, Deferiprone, Eliglustat, Acalabrutinib. The full list is on the Pyrimethamine page.
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