Interactions médicamenteuses
Carboprost tromethamine + Oxytocin
Gravité: Majeure
Carboprost tromethamine and Oxytocin: major interaction.
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Résumé
Carboprost and oxytocin both stimulate uterine contraction, and used together their effects are potentiated. This is sometimes done deliberately for postpartum hemorrhage, but it raises the risk of uterine hypertonus and, before delivery, uterine rupture.
Ce que signifie cette interaction, en termes simples
Carboprost tromethamine and Oxytocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive uterotonic effect through prostaglandin F2-alpha receptor and oxytocin receptor stimulation.
Conduite à tenir
Use together only under obstetric supervision with continuous monitoring of uterine tone and fetal status where relevant. Avoid in the antepartum setting unless clearly indicated.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Oxytocin
- Dinoprostone + Oxytocin Majeure
- Ephedrine + Oxytocin Majeure
- Fexinidazole + Oxytocin Majeure
- Givinostat + Oxytocin Majeure
- Misoprostol + Oxytocin Majeure
- Oxytocin + Phenylephrine Majeure
Questions fréquentes
Can I take Carboprost tromethamine with Oxytocin?
MediHelp rates the interaction as major. Carboprost tromethamine and Oxytocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carboprost and oxytocin both stimulate uterine contraction, and used together their effects are potentiated. This is sometimes done deliberately for postpartum hemorrhage, but it raises the risk of uterine hypertonus and, before delivery, uterine rupture.
How serious is the interaction between Carboprost tromethamine and Oxytocin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only under obstetric supervision with continuous monitoring of uterine tone and fetal status where relevant. Avoid in the antepartum setting unless clearly indicated.
What other medicines interact with Oxytocin?
MediHelp also lists interactions of Oxytocin with, for example, Dinoprostone, Ephedrine, Fexinidazole. The full list is on the Oxytocin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
