Interactions médicamenteuses
Ephedrine + Oxytocin
Gravité: Majeure
Ephedrine and Oxytocin: major interaction.
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Résumé
Oxytocin may cause hypotension, and ephedrine is often used to treat it, but when given after oxytocin a vasopressor can contribute to severe hypertension. This is recognized with oxytocic drugs and vasoconstrictors, particularly in the postpartum period.
Ce que signifie cette interaction, en termes simples
Ephedrine and Oxytocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ephedrine belongs to Cardiovascular; Oxytocin belongs to Endocrine.
Pourquoi elle survient
Additive pressor effects of sympathomimetic vasoconstriction with oxytocic-related vascular effects.
Conduite à tenir
Monitor blood pressure frequently and titrate ephedrine in small doses when used with oxytocin. Avoid combining with other vasoconstrictors where possible.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Oxytocin
- Carboprost tromethamine + Oxytocin Majeure
- Dinoprostone + Oxytocin Majeure
- Fexinidazole + Oxytocin Majeure
- Givinostat + Oxytocin Majeure
- Misoprostol + Oxytocin Majeure
- Oxytocin + Phenylephrine Majeure
Autres interactions de Ephedrine
- Ephedrine + Isocarboxazid Contre-indiquée
- Ephedrine + Phenelzine Contre-indiquée
- Ephedrine + Procarbazine Contre-indiquée
- Ephedrine + Rasagiline Contre-indiquée
- Ephedrine + Selegiline Contre-indiquée
- Ephedrine + Tranylcypromine Contre-indiquée
Questions fréquentes
Can I take Ephedrine with Oxytocin?
MediHelp rates the interaction as major. Ephedrine and Oxytocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxytocin may cause hypotension, and ephedrine is often used to treat it, but when given after oxytocin a vasopressor can contribute to severe hypertension. This is recognized with oxytocic drugs and vasoconstrictors, particularly in the postpartum period.
How serious is the interaction between Ephedrine and Oxytocin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure frequently and titrate ephedrine in small doses when used with oxytocin. Avoid combining with other vasoconstrictors where possible.
What other medicines interact with Oxytocin?
MediHelp also lists interactions of Oxytocin with, for example, Carboprost tromethamine, Dinoprostone, Fexinidazole. The full list is on the Oxytocin page.
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