Interactions médicamenteuses
Cefaclor + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Gravité: Modérée
Cefaclor and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Dernière mise à jour
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Résumé
Sodium picosulfate is a prodrug that needs colonic bacteria to form its active laxative metabolite. Antibiotics given before bowel preparation may reduce this conversion and result in inadequate bowel cleansing before colonoscopy.
Ce que signifie cette interaction, en termes simples
Cefaclor and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pourquoi elle survient
Antibiotic suppression of colonic bacteria that convert sodium picosulfate to its active metabolite.
Conduite à tenir
Where possible, avoid starting the antibiotic before the preparation, or complete the course earlier. Confirm adequate bowel cleansing before the procedure.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Cefaclor
- Bcg vaccine live + Cefaclor Modérée
- Cefaclor + Cholera vaccine Modérée
- Cefaclor + Kanamycin Modérée
- Cefaclor + Microbiota Modérée
- Cefaclor + Plazomicin Modérée
- Cefaclor + Typhoid vaccine live Modérée
Questions fréquentes
Can I take Cefaclor with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Cefaclor and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate is a prodrug that needs colonic bacteria to form its active laxative metabolite. Antibiotics given before bowel preparation may reduce this conversion and result in inadequate bowel cleansing before colonoscopy.
How serious is the interaction between Cefaclor and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, avoid starting the antibiotic before the preparation, or complete the course earlier. Confirm adequate bowel cleansing before the procedure.
What other medicines interact with Cefaclor?
MediHelp also lists interactions of Cefaclor with, for example, Bcg vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefaclor page.
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