Interactions médicamenteuses
Cefepime + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Gravité: Modérée
Cefepime and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Dernière mise à jour
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Résumé
Sodium picosulfate is a prodrug activated by colonic bacteria to its laxative form. Antibiotics that suppress colonic flora may reduce this activation and lead to a poorer bowel cleansing before colonoscopy. Systemically given cefepime has less gut effect than oral antibiotics, but labeling still cautions about antibiotics.
Ce que signifie cette interaction, en termes simples
Cefepime and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pourquoi elle survient
Antibiotic suppression of colonic bacteria needed to convert sodium picosulfate to its active metabolite.
Conduite à tenir
Where possible, avoid starting antibiotics shortly before the bowel prep, or confirm adequate cleansing and consider an alternative preparation if the antibiotic cannot be avoided.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Cefepime
- Amikacin + Cefepime Modérée
- Cefepime + Cholera vaccine Modérée
- Cefepime + Dexamethasone-tobramycin Modérée
- Cefepime + Gentamicin Modérée
- Cefepime + Kanamycin Modérée
- Cefepime + Microbiota Modérée
Questions fréquentes
Can I take Cefepime with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Cefepime and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate is a prodrug activated by colonic bacteria to its laxative form. Antibiotics that suppress colonic flora may reduce this activation and lead to a poorer bowel cleansing before colonoscopy. Systemically given cefepime has less gut effect than oral antibiotics, but labeling still cautions about antibiotics.
How serious is the interaction between Cefepime and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, avoid starting antibiotics shortly before the bowel prep, or confirm adequate cleansing and consider an alternative preparation if the antibiotic cannot be avoided.
What other medicines interact with Cefepime?
MediHelp also lists interactions of Cefepime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefepime page.
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