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Interactions médicamenteuses

Cefotaxime + Tobramycin

Gravité: Modérée

Cefotaxime and Tobramycin: moderate interaction.

Dernière mise à jour

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Résumé

Combining a cephalosporin with an aminoglycoside may raise the risk of kidney injury, and tobramycin itself can damage the kidneys and inner ear. The additive risk with cefotaxime is modest and mainly relevant in patients with renal impairment, older age or dehydration.

Ce que signifie cette interaction, en termes simples

Cefotaxime and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cefotaxime belongs to Anti Bacterial; Tobramycin belongs to Anti Bacterial.

Niveau de preuve: Low

Pourquoi elle survient

Possible additive nephrotoxicity, with reduced renal function leading to higher aminoglycoside exposure and greater ototoxic potential.

Conduite à tenir

Monitor serum creatinine and tobramycin trough levels, and adjust the dose to renal function. Keep the patient hydrated and assess hearing and balance if therapy is prolonged.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cefotaxime with Tobramycin?

MediHelp rates the interaction as moderate. Cefotaxime and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a cephalosporin with an aminoglycoside may raise the risk of kidney injury, and tobramycin itself can damage the kidneys and inner ear. The additive risk with cefotaxime is modest and mainly relevant in patients with renal impairment, older age or dehydration.

How serious is the interaction between Cefotaxime and Tobramycin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tobramycin trough levels, and adjust the dose to renal function. Keep the patient hydrated and assess hearing and balance if therapy is prolonged.

What other medicines interact with Cefotaxime?

MediHelp also lists interactions of Cefotaxime with, for example, Typhoid vaccine live, Amikacin, Cholera vaccine. The full list is on the Cefotaxime page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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